Nonconserved Ca /Calmodulin Binding Sites in Munc13s Differentially Control Synaptic Short-Term Plasticity
نویسندگان
چکیده
Noa Lipstein, Sabine Schaks, Kalina Dimova,* Stefan Kalkhof,* Christian Ihling, Knut Kölbel, Uri Ashery, JeongSeop Rhee, Nils Brose, Andrea Sinz, and Olaf Jahn Department of Molecular Neurobiology and Proteomics Group, Max Planck Institute of Experimental Medicine, Göttingen, Germany; Department of Pharmaceutical Chemistry & Bioanalytics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany; Department of Neurobiology, Faculty of Sciences, and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; and Deutsche Forschungsgemeinschaft Research Center for Molecular Physiology of the Brain, Göttingen, Germany
منابع مشابه
Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.
Munc13s are presynaptic proteins that mediate synaptic vesicle priming and thereby control the size of the readily releasable pool of vesicles. During high synaptic activity, Munc13-1 and its closely related homolog, ubMunc13-2, bind Ca(2+)/calmodulin, resulting in enhanced priming activity and in changes of short-term synaptic plasticity characteristics. Here, we studied whether bMunc13-2 and ...
متن کاملNon - conserved Ca 2 + / calmodulin binding sites in Munc 13 s differentially 1 control synaptic short - term plasticity 2 3
39 40 Munc13s are presynaptic proteins that mediate synaptic vesicle priming and thereby control 41 the size of the readily releasable pool of vesicles. During high synaptic activity, Munc13-1 42 and its closely related homolog ubMunc13-2 bind Ca 2+ /calmodulin, resulting in enhanced 43 priming activity and in changes of short-term synaptic plasticity characteristics. Here, we 44 studied whethe...
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